What changes did the COSMOS trial find in hsCRP levels after daily cocoa extract supplementation?
The COSMOS trial investigated whether cocoa flavanols can reduce inflammatory aging, or "inflammaging," which is linked to chronic diseases. Researchers specifically tracked high-sensitivity C-reactive protein (hsCRP) as a key marker for cardiovascular risk.
✓ Accepted answer
In the COSMOS trial, daily supplementation with cocoa extract led to a measurable decrease in high-sensitivity C-reactive protein (hsCRP) levels among participants.
- Study Design and Origin: The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) is a major randomized controlled trial conducted by researchers at Mass General Brigham. The specific findings regarding inflammation were published in the journal Age and Ageing, with the research team analyzing data from participants who received daily supplements over a multi-year period.
- Targeting Inflammaging: The primary focus was on reducing "inflammaging," the chronic low-grade inflammation associated with advanced age. By tracking five key age-related inflammatory markers, the study aimed to understand how plant-based interventions could mitigate biological aging processes.
- hsCRP as a Critical Marker: Researchers identified hsCRP as a pivotal indicator of cardiovascular risk. The data showed that participants consuming cocoa flavanols experienced a significant reduction in this specific marker, suggesting that the supplement helps dampen systemic inflammation linked to heart disease.
- Role of Cocoa Flavanols: The cocoa extract used in the trial is rich in flavanols, a type of polyphenol known for its antioxidant and anti-inflammatory properties. The findings indicate that these compounds may contribute to the observed drop in inflammatory markers, providing a biological mechanism for potential heart-protective effects.
- Practical Implications for Readers: While the trial supports the health benefits of flavanol-rich foods, it is part of a broader supplement regimen. For US and UK readers, this suggests that incorporating sources of cocoa flavanols may be a strategic component of a longevity-focused diet, particularly for older adults seeking to manage cardiovascular and inflammatory risks.
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